Fermented Papaya Boosts Immunity and Detoxification

Fermented papaya's boost immunity.

Fermented papaya’s boost immunity.

Fermented papaya is a delicious way to boost immunity and detoxification within the body. This is the conclusion of multiple research studies over the past decade.

Immunity boosted among hospital patients

A 2017 study from Japan’s Kyushu University studied elderly patients who were on tube feeding in the hospital. They separated the patients into three groups. They gave one group fermented papaya (Carica papaya Linn.) at different doses to each group. Before and after the trial, they tested the patients’ blood levels for immunity markers.

After 30 days, the patients had increased levels of immunity. This was detected with lower levels of peripheral blood mononuclear cell (PBMC) dieoffs. Those patients given the greater levels of fermented papaya also had greater levels of immunity.

Fermented papaya helps younger people too

In 2012, Italian researchers also found eating fermented papaya significantly increases immune function. Six weeks of fermented papaya, they also found, stimulates the body’s ability to detoxify. This occurs through detoxification enzymes such as superoxide dismutase.

The researchers, from Italy’s ReGenera Research Group for Aging Intervention Group in Milan, studied 90 healthy but sedentary human subjects. They divided the subjects into three groups by age (20-40 years old, 41-65 years old and over 65). They tested the subjects’ blood and saliva together with questionnaires prior to and after the papaya protocol.

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The researchers then gave half of each of the subjects from each group either a placebo or nine grams per day of fermented papaya.

After the six weeks, the subjects were again tested and given a month break (washout period). Then the the placebo group was given the fermented papaya while the previous papaya group was given the placebo. This research method is called a crossover.

Before and after each testing period the researchers performed blood analysis on the patients, checked for white blood cells count, checked saliva flow rates and secretary IgA activity. They also checked lysozymes and redox gene expression for Phase II enzymes and superoxide dismutase secretion from upper airway cells.

Immunoglobulin-A is an antibody produced by the body to help identify invaders and guard the body from infections.

The researchers found that those taking the fermented papaya had significantly greater IgA (immunoglobulin-A) levels than the placebo groups.

The researchers also found that phase II enzymes and superoxide dismutase enzyme expression was significantly higher among the papaya groups.

While these responses were seen among all of the age groups studied, the salivary secretion rates increased significantly in the youngest group. This is another sign of increased immune function.

Why superoxide dismutase secretion is important

Superoxide dismutase secretion is extremely important to the nose and airways because it helps neutralize reactive oxygen species and reactive nitrogen species – both considered free radicals that will damage the body’s cells if they are not neutralized. Many toxins and pollutants – especially air pollutants containing mercury, sulfur and other reactive elements from air pollution – will convert to radicals in the presence of oxygen, damaging lung and airway cells.

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Phase 2 enzymes include glutathione transferases and quinone reductases. These are important enzymes for preventing genetic mutations – and those preventing cancerous cells from forming.

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The researchers confirmed that while further testing was required to confirm their findings, fermented papaya stimulates the immune system especially among the cells of the upper airways.

The fermented papaya concoction used by the researchers was produced by the Osato Research Institute from Gifu, Japan. The product was taken sublingually, which means it was put under the tongue, allowing the nutrients to be quickly absorbed into the bloodstream. This method of sublingual absorption works well for a number of nutrients, including vitamin B12.

Fermented papaya reduces damage from free radicals

A 2013 study from French and Mauritius researchers found that fermented papaya reduced the blood’s susceptibility to free radical damage. The study collected blood cells before and after the consumption of fermented papaya (six grams per day for 14 weeks). The researchers found that the fermented papaya significantly reduced blood cells’ rate of hemolysis (destruction) through contact from free radicals.

Other fermented foods have also been shown by other research to stimulate the immune system. These include kimchi, kefir, yogurt, sauerkraut and others.

It should be noted that many papayas grown in Hawaii are now genetically modified.



Fujita Y, Tsuno H, Nakayama J. Fermented Papaya Preparation Restores Age-Related Reductions in Peripheral Blood Mononuclear Cell Cytolytic Activity in Tube-Fed Patients. PLoS One. 2017 Jan 6;12(1):e0169240. doi: 10.1371/journal.pone.0169240.

Marotta F, Naito Y, Jain S, Lorenzetti A, Soresi V, Kumari A, Carrera Bastos P, Tomella C, Yadav H. Is there a potential application of a fermented nutraceutical in acute respiratory illnesses? An in-vivo placebo-controlled, cross-over clinical study in different age groups of healthy subjects. J Biol Regul Homeost Agents. 2012 Apr-Jun;26(2):285-94.

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Somanah J, Bourdon E, Rondeau P, Bahorun T, Aruoma OI. Relationship between fermented papaya preparation supplementation, erythrocyte integrity and antioxidant status in pre-diabetics. Food Chem Toxicol. 2013 Dec 5;65C:12-17. doi: 10.1016/j.fct.2013.11.050.


  • Case Adams, Naturopath

    California Naturopath, Ph.D. in Natural Health Sciences, Doctorate in Integrative Health Sciences, Board Certified Alternative Medicine Practitioner. Diplomas in Blood Chemistry, Clinical Nutritional Counseling, Homeopathy, Aromatherapy, Colon Hydrotherapy, certificates in Pain Management and Case Management/Contact Tracing. Has authored more than 30 books and hundreds of periodical articles on natural medicine. Recreational activities include surfing, sailing, running, biking, swimming, SUPing, hiking. Contact: case(at)caseadams(dot)com.

    https://www.caseadams.com [email protected] Adams, Naturopath Case

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