Indigo Herb Compound Halts Cancer Growth

indigo inhibits cancer

Indigo constituent found to inhibit cancer growth.

Herbs contain many medicinal compounds. Many will inhibit the growth of cancer. This means they can help prevent and fight cancer. A constituent of the herb Indigo (Indigofera sumatrana) has been found to do just that – fight cancer.

Indigo halts lung cancer growth

Researchers from the Beckman Research Institute have determined that a constituent of the Indigo herb called indirubin prevents leukemia cells from growing. Another recent study from Korea’s Chosun University has found that indirubin stops lung cancer cell growth. And a 2011 study from Ohio State University showed indirubin stops brain cancer cells from growing.

The lung cancer research found that indirubin also blocked phosphorylation activities, and reduced the polo-like kinase (PLK) activity, which also leads to the cell death of human lung cancer cells.

Leukemia inhibited

The leukemia research, supported by the City of Hope Comprehensive Cancer Center’s department of molecular medicine, applied indirubin to human chronic myelogenous leukemia tumor cells. They found that the indirubin blocked the cancer cells’ signalling systems and their ability to regenerate their cell membranes—a process called autophosphorylation.

The mechanism revealed by the study involved blocking processes of particular genes within the tumor cells. Indirubin blocks the process of a protein called the Signal Transducer and Activator of Transcription 5 (STAT5) protein. In addition, a group of molecules called Src family kinases (SFKs) is blocked by indirubin, which prevents the cell from activating phosphorylation. This leads to cell death among the leukemia cells.

Other cancers halted

This is not the first study that has shown that indirubin shuts down cancer cells. A 2011 study showed that indirubin blocked the growth of brain cancer cells.

The anti-cancer promise

Boost the immune system by Case Adams

Discover other ways to boost immunity while supporting this ad-free website.

Indirubin is now seen as one of the most promising anti-cancer strategies available. Thanks to mother nature.

Indirubin was discovered well over a decade ago, when researchers were trying to isolate the compound within the Traditional Chinese Herbal formula called Danggui Longhui Wan that seemed to block leukemia cancer from growing. The Danggui Longhui Wan formula contains 11 different herbs, so, through the process of elimination, researchers have been able to gradually isolate which plant and which component the mechanism was coming from.

Eventually, the plant found to block cancer growth indigo, or Indigofera sumatrana, which is also called Indigofera tinctoria, and the active constituent was called indirubin.

Other research finds that artemisia also halts the growth of cancer. Watercress also inhibits cancer growth according to other research.

It should be noted that whole plant herbs and herbal combinations are used in traditional medicine because the variety of multiple constituents help buffer the active ones, providing a higher level of safety and lower levels of side effects.


Nam S, Scuto A, Yang F, Chen W, Park S, Yoo HS, Konig H, Bhatia R, Cheng X, Merz KH, Eisenbrand G, Jove R. Indirubin derivatives induce apoptosis of leukemia cells involving inhibition of Stat5 signaling. Mol Oncol. 2012 Feb 17.

Yoon HE, Kim SA, Choi HS, Ahn MY, Yoon JH, Ahn SG. Inhibition of Plk1 and Pin1 by 5′-nitro-indirubinoxime suppresses human lung cancer cells. Cancer Lett. 2012 Mar;316(1):97-104.

Williams SP, Nowicki MO, Liu F, Press R, Godlewski J, Abdel-Rasoul M, Kaur B, Fernandez SA, Chiocca EA, Lawler SE. Indirubins decrease glioma invasion by blocking migratory phenotypes in both the tumor and stromal endothelial cell compartments. Cancer Res. 2011 Aug 15;71(16):5374-80.


  • Case Adams, Naturopath

    California Naturopath, Ph.D. in Natural Health Sciences, Doctorate in Integrative Health Sciences, Board Certified Alternative Medicine Practitioner. Diplomas in Blood Chemistry, Clinical Nutritional Counseling, Homeopathy, Aromatherapy, Colon Hydrotherapy, certificates in Pain Management and Case Management/Contact Tracing. Has authored more than 30 books and hundreds of periodical articles on natural medicine. Recreational activities include surfing, sailing, running, biking, swimming, SUPing, hiking. Contact: case(at)caseadams(dot)com.

    View all posts
This site is Copyright Protected