A plant medicine from a common herb has shown promise in treating nervous system conditions like dementia, Alzheimer’s, multiple sclerosis, Parkinson’s and Huntington’s disease.
These effects have been found from research on the Ruta graveolens plant. This plant has traditionally been used for various purposes in herbal medicine. It has a long history of use in different cultures and is known for its medicinal properties.
In this article
What is Rue?
Ruta graveolens is called Common Rue. Rue is a flowering plant that belongs to the Rutaceae family and is native to the Balkan Peninsula.
It has a long history of medicinal use and has been traditionally employed in Eastern European and Western herbalism.
Rue has been used in these and other traditional medicines for centuries. It has been employed for its anti-inflammatory, analgesic, and antimicrobial effects. It has been used to alleviate menstrual pain, reduce inflammation, and treat digestive disorders. It has also been used with success on various rheumatic diseases, eye conditions, multiple sclerosis, skin dermatitis and pain.
Rue has been administered as fresh herbs, infusions (teas), extracts, oils and leaf powders.
Additionally, rue has been utilized as an insect repellent and for its potential anti-cancer properties.
Research on Ruta graveolens
In a 2020 study from the Italy’s University of Campania and the Department of Clinical Neuroscience, at Stockholm’s Karoliska Institutet, researchers found that rue exerted positive effects on the central nervous system. They found that its positive nerve effects had “wide spectrum activity.”
With regard to its nervous system effects, the herb has been found to be an active inhibitor of acetylcholinesterase (AChE). This anti-AChE effect gives rue the ability to improve memory and help with nervous system conditions.
A 2013 study found that it inhibits monoamine oxidase B (MAO-B) – which makes it able to slow the progression of dementia. Lab studies have also found it potentially helpful in Parkinson’s disease and Alzheimer’s as well. And a 2018 study found it could be useful in the treatment of Huntington’s disease.
A 2020 study found that Rue’s compounds provide what is called selective MAO-A and MAO-B inhibition. This means that it inhibits the MAO-A and -B without causing disruptive side effects that have been found in some MAO inhibiting drugs.
A 2018 study on Alzheimer’s disease in mice found that a Rue extract improved the mice without toxicity. And a 2019 mice study found that Rue extract improved symptoms in Parkinson’s disease.
What does Rue contain?
Rue contains a number of important medicinal compounds, including rutin and rutamarin. The later is a coumarin that belongs in a family of naturally-occurring compounds known to boost levels of dopamine and serotonin in the brain.
Rutamarin isn’t the only courmarin in the plant either. A 2015 study found the plant also contains three furanocoumarins, two quinolinic alkaloids and a dicoumarin.
Rutin is a flavonoid compound known for its antioxidant and anti-inflammatory properties. It has also been investigated for its neuroprotective (nervous system), nephroprotective (bladder), and hepatoprotective (liver) effects. Rutin is found in various plants.
Rutin has also been studied for its ability to help prevent diabetes complications.
Rutin is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antioxidant, neuroprotective, nephroprotective, and hepatoprotective effects. In this review, the antihyperglycemic property of rutin and its protective effects against the development of diabetic complications are discussed.
Rutamarin is another compound found in rue, and it has been investigated for its pharmacological activities, including antimicrobial and anticancer properties.
Meanwhile conditions such as Parkinson’s disease are related to a lack of dopamine production and availability.
Rue is not advisable during pregnancy. Talk to your doctor before dosing with herbal medicines.
Kozioł E, Luca SV, Ağalar HG, Sağlık BN, Demirci F, Marcourt L, Wolfender JL, Jóźwiak K, Skalicka-Woźniak K. Rutamarin: Efficient Liquid-Liquid Chromatographic Isolation from Ruta graveolens L. and Evaluation of Its In Vitro and In Silico MAO-B Inhibitory Activity. Molecules. 2020 Jun 9;25(11):2678. doi: 10.3390/molecules25112678.
Tao D, Wang Y, Bao XQ, Yang BB, Gao F, Wang L, Zhang D, Li L. Discovery of coumarin Mannich base derivatives as multifunctional agents against monoamine oxidase B and neuroinflammation for the treatment of Parkinson’s disease. Eur J Med Chem. 2019 Jul 1;173:203-212. doi: 10.1016/j.ejmech.2019.04.016.
Khan MM, Raza SS, Javed H, Ahmad A, Khan A, Islam F, Safhi MM, Islam F. Rutin protects dopaminergic neurons from oxidative stress in an animal model of Parkinson’s disease. Neurotox Res. 2012 Jul;22(1):1-15. doi: 10.1007/s12640-011-9295-2.
He Q, Liu J, Lan JS, Ding J, Sun Y, Fang Y, Jiang N, Yang Z, Sun L, Jin Y, Xie SS. Coumarin-dithiocarbamate hybrids as novel multitarget AChE and MAO-B inhibitors against Alzheimer’s disease: Design, synthesis and biological evaluation. Bioorg Chem. 2018 Dec;81:512-528. doi: 10.1016/j.bioorg.2018.09.010.
McColgan P, Tabrizi SJ. Huntington’s disease: a clinical review. Eur J Neurol. 2018 Jan;25(1):24-34. doi: 10.1111/ene.13413.
Colucci-D’Amato L, Cimaglia G. Ruta graveolens as a potential source of neuroactive compounds to promote and restore neural functions. J Tradit Complement Med. 2020 Jun 4;10(3):309-314. doi: 10.1016/j.jtcme.2020.05.002.
Russo P, Frustaci A, Del Bufalo A, Fini M, Cesario A. From traditional European medicine to discovery of new drug candidates for the treatment of dementia and Alzheimer’s disease: acetylcholinesterase inhibitors. Curr Med Chem. 2013;20(8):976-83.
Ghorbani A. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother. 2017 Dec;96:305-312. doi: 10.1016/j.biopha.2017.10.001.
Mancuso G, Borgonovo G, Scaglioni L, Bassoli A. Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception. Molecules. 2015 Oct 16;20(10):18907-22. doi: 10.3390/molecules201018907.