Studies: Plant-based Low Carb Diet Aids Weight Loss, Cholesterol

low-carb vegan diet

Plant-based low carbs increase weight loss efforts

University researchers have found that a low-carb plant-based diet helps lose weight and reduce bad cholesterol, including LDL-c  and triglycerides.

The research was led by David J.A. Jenkins, MD, PhD, DSc, Professor of Nutrition at the University of Toronto.

The researchers tested two diets that have been found to reduce LDL-c, triglycerides and produce weight loss. In their introduction and analysis of previous research, the researchers wrote in the British Medical Journal, Lancet (the statements below were referenced to a list of 32 clinical research findings – see references below*):

“Many popular weight loss diets emphasize carbohydrate restriction (Atkins, Eddies, South Beach, Zone). However, a high content of animal products, rich in saturated fat and cholesterol, may make conventional low-carbohydrate diets less appropriate for those with hypercholesterolaemia. Even during active weight loss, these high-saturated fat diets do not lower serum low-density lipoprotein cholesterol (LDL-C) below baseline and there is concern that if such diets continue to be eaten when weight loss has ceased, a more atherogenic blood lipid profile may result. These concerns have prompted exploration of other weight loss strategies, but only modest reductions in LDL-C have been observed.

“By contrast vegan diets significantly lower LDL-C. Trials of vegan and vegetarian diets also reduce progression of coronary heart disease and improve diabetes control. Plant food components such as vegetable proteins, vegetable oils, nuts and viscous fibers, reduce serum lipids in many studies and may increase flow-mediated vasodilatation. Nuts, fiber and vegetarian diets in general, all reduce coronary heart disease and diabetes in cohort studies. Finally, in cohort studies, low-carbohydrate diets, high in vegetable oils and proteins as opposed to animal products, reduce coronary heard disease events and diabetes incidence in women, while lower red meat intake reduces total, cardiovascular and cancer mortality. Most recently a large randomized controlled trial confirmed the effect of nuts and increased vegetable oil (olive oil) intake in reducing cardiovascular events in the context of a Mediterranean diet.”

Moving forward from these previous research findings, the researchers conducted a clinical study that tested two diets: A lacto-ovo vegetarian diet and a low-carb plant-based diet, with its protein coming from foods like nuts, gluten-containing grains and soy. The choices of higher-protein foods was “self-selected” by the participants – meaning they ate selected foods they preferred to eat.

In all, 23 human adults who were overweight with metabolic disease symptoms (lack of glucose control) completed the six month study. At the beginning and the end of the study, weight, LDL-c, triglycerides, total cholesterol and apolipoprotein B:A1 ratios were measured among the subjects.

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After the six months, the plant-based low-carb group lost an average of 7 kilograms each – equivalent to over 15 pounds – and those on the lacto-ovo diet lost an average of nearly 13 pounds each.

And both groups also had significantly lower LDL and triglyceride levels. The plant-based low-carb diet resulted in an average reduction of 27 mg/dL in LDL-c levels, and the lacto-ovo diet resulted in an average reduction of almost 11 mg/dL in LDL-c – still a significant result.

Reduced triglycerides

Meanwhile, the plant-based low-carb diet participants saw their average triglyceride levels go down by over 50 mg/dL while the lacto-ovo group’s triglycerides went down by almost 10 mg/dL.

Both of these factors – LDL-c and triglycerides – are significantly linked with heart disease.

Furthermore, levels of Apo B/A1 – also linked to heart disease – went down significantly, dropping by 0.57 in the plant-based low-carb diet and 0.05 in the lacto-ovo diet.

The researchers concluded that the plant-based low-carb diet…:

“containing increased protein and fat from gluten and soy products, nuts and vegetable oils, had lipid lowering advantages over a high-carbohydrate, low-fat weight loss diet, thus improving heart disease risk factors.”

Other research has found that a low-carb diet with greenfoods can significantly improve weight loss efforts.

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Jenkins DJ, Wong JM, Kendall CW, Esfahani A, Ng VW, Leong TC, Faulkner DA, Vidgen E, Paul G, Mukherjea R, Krul ES, Singer W. Effect of a 6-month vegan low-carbohydrate (‘Eco-Atkins’) diet on cardiovascular risk factors and body weight in hyperlipidaemic adults: a randomised controlled trial. BMJ Open. 2014 Feb 5;4(2):e003505. doi: 10.1136/bmjopen-2013-003505.

Samaha FF, Iqbal N, Seshadri P, et al. A low-carbohydrate as compared with a low-fat diet in severe obesity. N Engl J Med 2003;348:2074–81.

Foster GD, Wyatt HR, Hill JO, et al. A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med 2003;348:2082–90.

Stern L, Iqbal N, Seshadri P, et al. The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial. Ann Intern Med 2004;140:778–85.

Read more:  Plant Fats Reduce Heart Disease over Dairy and Animal Fats

Dansinger ML, Gleason JA, Griffith JL, et al. Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA 2005;293:43–53.

Gardner CD, Kiazand A, Alhassan S, et al. Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A to Z Weight Loss Study: a randomized trial. JAMA 2007;297:969–77.

Sacks FM, Bray GA, Carey VJ, et al. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med 2009;360:859–73.

Foster GD, Wyatt HR, Hill JO, et al. Weight and metabolic outcomes after 2 years on a low-carbohydrate versus low-fat diet: a randomized trial. Ann Intern Med 2010;153:147–57.

Anderson JW, Randles KM, Kendall CW, et al. Carbohydrate and fiber recommendations for individuals with diabetes: a quantitative assessment and meta-analysis of the evidence. J Am Coll Nutr 2004;23:5–17.

Shai I, Schwarzfuchs D, Henkin Y, et al. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N Engl J Med 2008;359:229–41.

Sacks FM, Ornish D, Rosner B, et al. Plasma lipoprotein levels in vegetarians. The effect of ingestion of fats from dairy products. JAMA 1985;254:1337–41.

Ornish D, Brown SE, Scherwitz LW, et al. Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial. Lancet 1990;336:129–33.

Barnard ND, Cohen J, Jenkins DJ, et al. A low-fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetes. Diabetes Care 2006;29:1777–83.

Jenkins DJ, Newton C, Leeds AR, et al. Effect of pectin, guar gum, and wheat fibre on serum-cholesterol. Lancet 1975;1:1116–17.

Sirtori CR, Agradi E, Conti F, et al. Soybean-protein diet in the treatment of type-II hyperlipoproteinaemia. Lancet 1977;1:275–7.

Grundy SM. Comparison of monounsaturated fatty acids and carbohydrates for lowering plasma cholesterol. N Engl J Med 1986;314:745–8.

Anderson JW, Johnstone BM, Cook-Newell ME. Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med 1995;333:276–82.

Kris-Etherton PM, Yu-Poth S, Sabate J, et al. Nuts and their bioactive constituents: effects on serum lipids and other factors that affect disease risk. Am J Clin Nutr 1999;70(3 Suppl):504S–11S.

Sabate J, Oda K, Ros E. Nut consumption and blood lipid levels: a pooled analysis of 25 intervention trials. Arch Intern Med 2010;170:821–7.

Ros E, Nunez I, Perez-Heras A, et al. A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. Circulation 2004;109:1609–14.

Read more:  Pectin and Balancing Blood Sugar

Zhao G, Etherton TD, Martin KR, et al. Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women. J Nutr 2004;134:2991–7.

West SG, Krick AL, Klein LC, et al. Effects of diets high in walnuts and flax oil on hemodynamic responses to stress and vascular endothelial function. J Am Coll Nutr 2010;29:595–603.

Ma Y, Njike VY, Millet J, et al. Effects of walnut consumption on endothelial function in type 2 diabetic subjects: a randomized controlled crossover trial. Diabetes Care 2010;33:227–32.

Appleby PN, Thorogood M, Mann JI, et al. The Oxford Vegetarian Study: an overview. Am J Clin Nutr 1999;70(3 Suppl):525S–31S.

Fraser GE. Diet, life expectancy, and chronic disease: studies of Seventh-Day Adventists and other vegetarians. New York: Oxford University Press, 2003.

Pereira MA, O’Reilly E, Augustsson K, et al. Dietary fiber and risk of coronary heart disease: a pooled analysis of cohort studies. Arch Intern Med 2004;164:370–6.

Li TY, Brennan AM, Wedick NM, et al. Regular consumption of nuts is associated with a lower risk of cardiovascular disease in women with type 2 diabetes. J Nutr 2009;139:1333–8.

Kris-Etherton PM, Hu FB, Ros E, et al. The role of tree nuts and peanuts in the prevention of coronary heart disease: multiple potential mechanisms. J Nutr 2008;138:1746S–51S.

Pan A, Sun Q, Manson JE, et al. Walnut consumption is associated with lower risk of type 2 diabetes in women. J Nutr 2013;143:512–18.

Halton TL, Willett WC, Liu S, et al. Low-carbohydrate-diet score and the risk of coronary heart disease in women. N Engl J Med 2006;355:1991–2002.

Halton TL, Liu S, Manson JE, et al. Low-carbohydrate-diet score and risk of type 2 diabetes in women. Am J Clin Nutr 2008;87:339–46.

Pan A, Sun Q, Bernstein AM, et al. Red meat consumption and mortality: results from 2 prospective cohort studies. Arch Intern Med 2012;172:555–63.

Estruch R, Ros E, Salas-Salvado J, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013;368:1279–90.


  • Case Adams, Naturopath

    California Naturopath, Ph.D. in Natural Health Sciences, Doctorate in Integrative Health Sciences, Board Certified Alternative Medicine Practitioner. Diplomas in Blood Chemistry, Clinical Nutritional Counseling, Homeopathy, Aromatherapy, Colon Hydrotherapy, certificates in Pain Management and Case Management/Contact Tracing. Has authored more than 30 books and hundreds of periodical articles on natural medicine. Recreational activities include surfing, sailing, running, biking, swimming, SUPing, hiking. Contact: case(at)caseadams(dot)com.

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