Regardless of what name we give this plant, Nigella seeds have been used to treat numerous conditions among traditional medicines. These medicines include Ayurveda, Asian, Greek, Egyptian and Middle Eastern traditional medicines.
Black seed, also known as black cumin, black caraway, or by its scientific name Nigella sativa, is an annual flowering plant. The plant has finely divided, feathery leaves and pale blue or white flowers. The fruit is a large, inflated capsule composed of three to seven follicles, each containing numerous seeds. The seeds are small, black, and crescent-shaped.
Habitat
Nigella sativa is native to South and Southwest Asia but is now cultivated in various parts of the world, including the Middle East, Southern Europe, and North Africa. It grows well in well-drained, fertile soils and prefers a sunny location.
Primary Compounds
Black seed contains several bioactive compounds, including:
Thymoquinone: The most studied active component, known for its antioxidant, anti-inflammatory, and anticancer properties.
Nigellone: An effective bronchodilator and anti-histaminic agent.
Fixed Oils: Such as linoleic acid and oleic acid, which contribute to its anti-inflammatory and antioxidant effects.
Alkaloids: Including nigellicine and nigellidine, with potential therapeutic effects.
Saponins: Such as alpha-hederin, known for their immune-boosting properties.
Here's a list of compounds in this herb:
• thymoquinone
• thymohydroquinone
• dithymoquinone
• cymene
• carvacrol
• terpineol
• anethol
• longifolene
• pinene
• thymol
• nigellicimine
• nigellidine
• nigellicine
• hederin
• saponin
• carvone
• limonene
• citronellol
• carotene
• vanillic acid
• linoleic acid
• oleic acid
• eicodadienoic acid
• dihomolinoleic acid
• palmitic acid
• stearic acid
• sitosterol
• stigmasterol
Traditional Uses
Black seed has a rich history of use in traditional medicine across various cultures:
Middle Eastern Medicine: Often referred to as the "seed of blessing," black seed has been used to treat a wide range of ailments, including respiratory issues, digestive problems, and infections.
Ayurveda: Used for its warming properties to stimulate digestion, boost immunity, and treat respiratory conditions.
Traditional Chinese Medicine: Employed for its ability to improve liver function, treat digestive issues, and enhance overall vitality.
Health Benefits
The health benefits of black seed are primarily attributed to its rich composition of thymoquinone and other bioactive compounds:
Antioxidant: Thymoquinone and other compounds help protect cells from oxidative damage, reducing the risk of chronic diseases.
Anti-inflammatory: Black seed has potent anti-inflammatory effects, which can help in conditions like arthritis, asthma, and inflammatory bowel disease.
Immune Boosting: Saponins and other compounds in black seed enhance the immune system's response.
Antimicrobial: Effective against a wide range of pathogens, including bacteria, viruses, and fungi.
Digestive Health: Traditionally used to treat digestive issues such as bloating, gas, and indigestion.
Respiratory Health: Nigellone acts as a bronchodilator, helping to relieve asthma and other respiratory conditions.
Cancer Prevention: Thymoquinone has been studied for its potential anti-cancer properties, including its ability to induce apoptosis (programmed cell death) in cancer cells.
Let's take a look at some of black seed's specific benefits:
1. Asthma and lung function
Two 2017 clinical studies on Nigella seeds have proven its ability to treat lung conditions.
A study from the UK’s University College London and Saudi Arabia’s King Abdulaziz University conducted a clinical trial on 80 asthma patients. The researchers gave 40 of the patients 500 milligrams of Nigella seed oil in capsules twice a day for four weeks. The other 40 patients were given a placebo.
After the four weeks, those taking the Nigella seed oil had significantly fewer asthma attacks (better control of their asthma). They also had significantly lower blood eosinophils and better forced expiratory volume.
In a study from Saudi’s University of Dammam, 77 asthma patients were divided into three groups. One group was given 1 gram of Nigella seed oil per day for 12 weeks. Another group was given 2 grams per day, and the third group was given a placebo.
After the 12 weeks, both Nigella groups had significantly reduced asthma attacks and better scores in lung tests. These included the fractional exhaled nitric oxide test (FeNO), the peak expiratory flow test (PEF) and other lung tests. The Nigella group also had improved IgE levels and improved cytokines.
2. Ulcers and heartburn
Nigella seed has been used as a treatment for ulcerative conditions. One reason for this use is the seed oil’s ability to inhibit Helicobacter pylori – overgrowth involved in many ulcerative conditions.
A 2015 study of 70 patients with chronic dyspepsia were treated with either Nigella seed oil with honey (5 milliliters/day) or placebo for 8 weeks. The black seed group had significantly improved symptoms compared to the placebo group.
A 2010 study of 88 ulcer patients tested Nigella seed oil against triple therapy antibiotics. The eradication of H. pylori was accomplished equally between the Nigella group and the antibiotic group.
3. Diabetes and Glycemic Control
Several studies have tested Nigella seed’s ability to control diabetes. A 2017 study of 114 type-2 diabetes patients were given 2 grams per day of Nigella seed oil for a year or a placebo. The Nigella group had lower levels of triglycerides. low density lipoprotein cholesterol (LDL-c), systolic and diastolic blood pressure, heart rate (HR), and lower body mass index.
The black seed group also had lower levels of fasting blood sugar and reduced glycosylated hemoglobin (HbA1c) levels. Insulin resistance was also significantly lower and beta-cell activity was significantly greater.
A 2010 clinical study of 94 diabetes patients found that 2 grams per day of Nigella seed oil significantly reduced fasting blood sugar levels and lower HbA1c after two months.
Glycemic Control
Medical research has also found that black seed can improve glycemic control among diabetics.
The study gave 94 human diabetics either one gram, two grams or three grams per day of Nigella sativa in capsules for three months.
The patients’ glycemic control was tested before, during and after the treatment period using fasting blood glucose, blood glucose levels after eating, and glycosylated hemoglobin levels. They also measured C-peptide levels, insulin resistance, beta-cell function and changes in weight among the patients.
After only four weeks, the researchers, from Saudi Arabia’s King Faisal University College of Medicine, found that two grams per day of the Black seed significantly reduced fasting and post-meal blood glucose levels, and glycosylated hemoglobin levels. The improvement increased at eight weeks and 12 weeks.
For example, fasting blood glucose levels went down by 45 mg/dl at four weeks, 62 mg/dl at eight weeks, and 56 mg/dl after 12 weeks of taking the Nigella sativa seed.
Other diabetic parameters also improved during the treatment. Insulin resistance reduced, and Beta-cell function improved significantly with the two grams/day treatment program.
The one gram/day also led to improvements, but not as significant as the improvements found using two grams per day.
The researchers also found no adverse side effects from the natural treatment.
4. Hashimoto’s thyroiditis
A 2016 study of 40 patients with Hashimoto’s was treated with powdered Nigella seed oil for 8 weeks or placebo. The Nigella group had significantly lower TSH (thyroid stimulating hormone and lower anti-thyroid peroxidase (anti-TPO) levels. They also had reduction of Hashimoto’s symptoms and reduced serum VEGF concentrations.
5. Breast pain (Cyclic mastalgia)
A 2016 study of 156 women suffering from cyclic mastalgia were divided into three groups. They were treated with either N. sativa oil (topically), diclofenac or placebo. The Nigella seed oil group significantly reduced pain after one and two months among the patients. The effect of the black seed oil was similar to the effect of the topical diclofenac treatment.
6. Cancer
Nigella seed has been tested against human cancer cells on various occasions. These have included breast cancer, cervical cancer, bone cancer and others. In most of these cases, Nigella extracts were found to inhibit the growth of cancer cells.
7. Allergies
A 2011 study of 66 allergy patients found that Nigella seed reduced runny nose, sneezing attacks and nasal congestion after 30 days. Other studies have shown Nigella is an anti-inflammatory agent.
8. Heart disease
Studies have shown that black cumin will reduce blood pressure and reduce thrombosis. A 2008 study of heart patients found 100 and 200 milligrams of N. sativa extract per day for eight weeks significantly decreased diastolic and systolic blood pressure levels. The black seed extract also reduced LDL levels among the patients.
A 2014 study of 37 menopausal women found that N. sativa seed oil significantly reduced LDL-c and triglycerides, while increasing HDL-c levels.
9. Obesity
A 2015 study tested 84 obese women. Researchers gave 43 women 3 grams of Nigella seed oil per day and the rest were given a placebo. After eight weeks, the black seed group had significantly reduced waist circumference, lower weight. This is despite the fact that they continued to eat the same amount of calories. The black cumin group also had lower LDL levels.
10. Epilepsy
A 2007 study of 23 epileptic children found that black cumin seed oil significantly reduced seizures compared to the placebo group – who were also taking seizure control drugs. The treatment period was four weeks.
A 2013 study found similar results.
11. Mood and cognition
In a 2013 study, Nigella seed oil or placebo was given to 48 young men between 14 and 17 years old for four weeks. They were given 500 milligrams seed extract per day. The seed group had significantly reduced anxiety levels, better moods and increase long-term free recall.
Another 2013 study tested 40 volunteers for 9 weeks with 500 mg per day. This study also found the black seed oil group had enhanced memory, attention and cognition levels.
12. Bacteria infections
Nigella seed oil is a potent antibacterial agent. Studies have shown that Nigella seed inhibits the growth of potent bacteria strains such as Staphylococcus aureus ATCC 25923 and Staphylococcus epidermidis. This makes Nigella seed oil useful for skin infections and internal infections.
13. Candida and other fungal infections
Several studies have shown that Nigella seed is a potent antifungal agent. Studies have shown it inhibits a variety of strains of Candida albicans.
It also has been shown to inhibit other fungal infections such as toe and toenail fungus and ringworm:
-Trichophyton rubrum
-Trichophyton interdigitale
-Trichophyton mentagrophytes
-Epidermophyton floccosum
-Microsporum canis
14. Parasites
Nigella seed oil has been tested against parasites including different species of Schistosoma mansoni. These also include the different stages. The research has found Nigella inhibited parasitic infections.
15. Arthritis
A 2012 study of 40 women with rheumatoid arthritis were divided into two groups. One group was given 1 gram of Nigella oil in capsules per day for one month. The others were given a placebo. After the month, swollen joint levels decreased, and mobility increased for those given the black seed oil. RA scores were also higher among those given the herbal treatment.
Rich phytochemistry
Really? Nigella improves all these conditions? The reason may lie in the fact that Nigella contains numerous medicinal compounds. These include:
This array of phytochemistry adds up to only one thing: The fact that Nigella seeds are seriously medicinal.
REFERENCES:
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Badar A, Kaatabi H, Bamosa A, Al-Elq A, Abou-Hozaifa B, Lebda F, Alkhadra A, Al-Almaie S. Effect of Nigella sativa supplementation over a one-year period on lipid levels, blood pressure and heart rate in type-2 diabetic patients receiving oral hypoglycemic agents: nonrandomized clinical trial. Ann Saudi Med. 2017 Jan-Feb;37(1):56-63. doi: 10.5144/0256-4947.2017.56.
Salem AM, Bamosa AO, Qutub HO, Gupta RK, Badar A, Elnour A, Afzal MN. Effect of Nigella sativa supplementation on lung function and inflammatory mediatorsin partly controlled asthma: a randomized controlled trial. Ann Saudi Med. 2017 Jan-Feb;37(1):64-71. doi: 10.5144/0256-4947.2017.64.
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